Soon she was a semi-regular guest actress on the TV series "Family Ties." And though it took awhile, Cox - who turns 45 today - finally broke through in 1994 in a big way, playing Monica Geller in the sitcom "Friends."

Since that show ended in 2004, Cox has remained active in televsion and movies. She's married to David Arquette, a scion of one of Hollywood's most prominent families.
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